(1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Boceprevir
CAS: 394730-60-0
Molecular Formula: C27H45N5O5
(1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide - Names and Identifiers
(1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide - Physico-chemical Properties
| Molecular Formula | C27H45N5O5 |
| Molar Mass | 519.68 |
| Density | 1.162 |
| Melting Point | >107°C (dec.) |
| Solubility | Soluble in DMSO (up to 15 mg/ml with warming) |
| Appearance | solid |
| Color | White or off-white |
| pKa | 12.82±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
(1R,2S,5S)-N-(4-Amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide - Reference Information
| pharmacokinetics | boriprivir is excreted mainly by the liver, in patients with abnormal liver function, the peak blood concentration of the drug and the area of the curve under the drug were increased, but the elimination half-life of the drug was not different from that of the healthy people. In patients with end-stage renal insufficiency, there is no significant difference between the drug metabolism dynamic indexes of the drug and the healthy people, and the product cannot be cleared by hemodialysis. Therefore, in patients with hepatic and renal insufficiency, dose reduction is not required when using boribrivir. |
| Use | boribrivir is an oral hepatitis C Virus nonstructural protein 3/4A serine protease inhibitor, both act directly on the Virus enzyme domain, I .e., the Virus protease. By binding to NS3/4ASP, it acts to inhibit Virus of the replication. Borivir is a hepatitis C Virus NS3 serine protease inhibitor used to treat hepatitis C Virus infection. Is a Severe Acute Respiratory Syndrome Coronavirus 2 related research product. |
| indication | , for the treatment of chronic hepatitis C CHC infection in combination with pegylated interferon alpha and ribavirin genotype 1 in Adults with compensated liver disease (≥ 18 years), including cirrhosis, patients with previously untreated or previously failed interferon and ribavirin therapy. |
| biological activity | Boceprevir (EBP 520, SCH 503034) is an oral, direct acting hepatitis C virus (HCV) the inhibitor of protease has a Ki value of 14 nM for the NS3 protease. In the treatment of chronic hepatitis C(genotype 1), it is often co-administered with other antivirals. |
| Target | TargetValue NS3/4A protease () 14 nM(Ki) |
| Target | Value |
| NS3/4A protease () | 14 nM(Ki) |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: Boceprevir Visit Supplier Webpage Request for quotationCAS: 394730-60-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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